Diabetes FAQ

insulin rejection

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Q: How do I get Diabetes back on track?
Ive been a diabetic for 11 years now. Im now 22 years old. About a year ago, I stopped taking my insulin and eating anything i wanted. Dont ask me why, i was just an idiot. Since then, Ive lost a lot of weight, about 25 pounds ( i was already skinny so its a big difference) and my blood sugar has gone WAYYY up. Ive recently started takin my insulin again and gained about 5 pounds. Does the weight loss have anything to do with insulin rejection?… Also i was wondering what is a really good diet to follow, that wont leave me starving after a meal. Thanks for reading guys.

A: The fact that type 1 diabetes is due to the failure of one of the cell types of a single organ with a relatively simple function (i.e. the failure of the islets of Langerhans) has led to the study of several possible schemes to cure this form diabetes mostly by replacing the pancreas or just the beta cells. In contrast, type 2 diabetes is more complex, with fewer prospects of a curative measure, but further understanding of the underlying mechanism of insulin resistance may make a cure possible in the future. Correcting insulin resistance would provide a cure for type 2 diabetes in many cases.

Only those type 1 diabetics who have received a kidney-pancreas transplant (when they have developed diabetic nephropathy) and become insulin-independent may now be considered “cured” from their diabetes. Still, they generally remain on long-term immunosuppressive drug and there is a possibility the autoimmune phenomenon will develop in the transplanted organ.

Transplants of exogenous beta cells have been performed experimentally in both mice and humans, but this measure is not yet practical in regular clinical practice. Thus far, like any such transplant, it has provoked an immune reaction and long-term immunosuppressive drugs will be needed to protect the transplanted tissue. An alternative technique has been proposed to place transplanted beta cells in a semi-permeable container, isolating and protecting them from the immune system. Stem cell research has also been suggested as a potential avenue for a cure since it may permit regrowth of Islet cells which are genetically part of the treated individual, thus perhaps eliminating the need for immuno-suppressants. However, it has also been hypothesised that the same mechanism which led to islet destruction originally may simply destroy even stem-cell regenerated islets. A 2007 trial of 15 newly diagnosed patients with type 1 diabetes treated with stem cells raised from their own bone marrow after immune suppression showed that the majority did not require any insulin treatment for prolonged periods of time.

Microscopic or nanotechnological approaches are under investigation as well, in one proposed case with implanted stores of insulin metered out by a rapid response valve sensitive to blood glucose levels. At least two approaches have been demonstrated in vitro. These are, in some sense, closed-loop insulin pumps.[citation needed]

A new discovery might have important implications for treatment of diabetes. Researchers at the Toronto Hospital for Sick Children injected capsaicin into NOD mice (Non-obese diabetic mice, a strain that is genetically predisposed to develop the equivalent of type 1 diabetes) to kill the pancreatic sensory nerves. This treatment reduced the development of diabetes in these mice by 80%, suggesting a link between neuropeptides and the development of diabetes. When the researchers injected the pancreas of the diabetic mice with sensory neuropeptide (sP), they were ‘cured’ of the diabetes for as long as 4 months. Also, insulin resistance (characteristic of type 2 diabetes) was reduced. These research results are in the process of being reproduced, and their applicability in humans will have to be established in future. Any treatment that might result from this research is probably years away.

Q: What are ways of preventing diabetes?
I have dark skin around my neck, a “sign of insulin rejection” according to my doctor. How can I increase my chances of not getting diabetes? My grandmother has it.

A: You are smart to ask. Your doctor should guide you. There are three ways to manage glucose (blood sugar).
1. Diet
2. Exercise
3. Medication
Perhaps your doc could refer you to a diabetic nutritionist to assist you. I have diabetes, and trust me….if I had known then what I know now, I would have done everything I could to avoid it. A free site: www.fitday.com can help you track the carbs (which turn to sugar) in you diet. Hope it helps.

Peace be with you!

Q: I just started taking metformin?
And I ran out of pills and somehow put off getting them and it’s been about 5 days since I’ve taken them. I take 500 mg a day for PCOS and insulin rejection. I did get my pills today, just wondering if anybody can give me some information on their experience with Metformin, and is there any problems with going a couple days without it? Also, I see that you are not to consume any alcohol with Metformin, what happens with that. Any information in general is good. Thanks!

A: Metformin (INN; trade names Glucophage, Riomet, Fortamet, Glumetza, Diabex, Diaformin, and others) (IPA: /mɛtˈfɔrmɪn/) is an oral anti-diabetic drug from the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, particularly in overweight and obese people and those with normal kidney function.[1][2][3] Metformin is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic metformin alone.[4] As of 2007, it is one of only two oral anti-diabetics in the World Health Organization Model List of Essential Medicines (the other being glibenclamide).[5]
The main use for metformin is in the treatment of diabetes mellitus type 2, especially when this accompanies obesity and insulin resistance. Metformin is the only anti-diabetic drug that has been proven to reduce the cardiovascular complications of diabetes, as shown in a large study of overweight patients with diabetes.[10] Unlike the other most-commonly prescribed class of oral diabetes drugs, the sulfonylureas, metformin (taken alone) does not induce hypoglycemia.[11] Hypoglycemia during intense exercise has been documented, but is extremely rare.[12] It also does not cause weight gain, and may indeed produce minor weight loss.[13] Metformin also modestly reduces LDL and triglyceride levels.[14]

It is also being used increasingly in polycystic ovarian syndrome (PCOS),[15] non-alcoholic fatty liver disease (NAFLD)[16] and premature puberty,[17] three other diseases that feature insulin resistance; these indications are still considered experimental. Although metformin is not licenced for use in PCOS, the United Kingdom’s National Institute for Health and Clinical Excellence recommends that women with PCOS and a body mass index above 25 be given metformin when other therapy has failed to produce results.[18] The benefit of metformin in NAFLD has not been extensively studied and may be only temporary.[19]

It may reduce weight gain in patients taking atypical antipsychotics
A review of intentional and accidental metformin overdoses reported to Poison control centers over a 5-year period found that serious adverse events were rare, though elderly patients appeared to be at greater risk.[40] Intentional overdoses with up to 63 g of metformin have been reported in the medical literature.[41] The major potentially life-threatening complication of metformin overdose is lactic acidosis. Treatment of metformin overdose is generally supportive, but may include sodium bicarbonate to address acidosis and standard hemodialysis or continuous veno-venous hemofiltration to rapidly remove metformin and correct acidosis.[42][43]

Q: What is wrong with my body, did depo do this to me?
I took depo provera 2.5 yrs ago for 6 mon. I now feel constantly anxious, gained 50lbs w/excerse im up to 250. my mother and stepfather of 10 years got divorced and my dad almost died around the same time I started depo. I dont sleep, when i do i ve been told i often stop breathing for extended time. I cant afford medical. I am a college student. After depo I got on a diff birth control w/MORE ESTROGEN (stupid health dept.) which caused more problems, when i stopped the new bc my armpit and leg hair has almost stopped growing (yay for not having to shave often) and my periods became up to 8 wks apart. I was and still am overly emotional alot, I cry or yell at the stupidest things. My periods got back to normal after 3 months of progesterone cream. I was told i was prediabetic several years ago and have recently been told it could be metabolic insulin rejection. my thyroid is fine I still feel super anxious about daily things and let little things drive me nuts. what’s wrong w/me

A: This has absolutely nothing to do with taking Depro-provera. You may gain a small amount of weight (5 lbs or so) while on birth control but not 50. It’s impossible.

You obviously have been under a lot of stress and your eating may be emotional and unconscious. Other than that…. you need to make a list of your symptoms and when you get them and then make an appointment with your family doctor. You may be suffering from a bit of depression/anxiety after everything that you’ve been through. As for not being able to afford medical attention, every college has a free clinic for it’s student, go there.

Q: Surface piercing rejection?
On Tuesday I got a surface piercing uner my bellybutton and I think it’s rejecting. I got it at a nice place that I’ve seen/had 10 piercings from there. I feel it’s just my body because my friend got two surface piercings from there and they are fine.

First off the bar seems really close to the surface of my skin (I felt my friends and hers is not). The balls seem indented in my skin and are a little red but not too much where it would be alarming. What really bothered me was it hurt alot yesterday, maybe because its so close to my pants line? It didn’t hurt today though. Where the balls hit the bar it is the most apparent part you can feel. However I cannot see the bar through the skin and its not badly bruised. One of the girls I work with has insulin needles and she says her skin looks the same way when she puts them in and it could just be my body getting used to it. I know there is no way to stop it so I’ll just take it out when I see my piercer on Sunday.

Any suggestions?

A: Stay away from there and find a new spot.

Q: Does anyone have faith in Disease Cures…….?
It seems like nothing big has ever been cured, we just keep adding new diseases. Being diabetic, I thought this would be an easy cure because if your pancreas doesn’t work islets of langerhorn can be injected into your pancreas and work to produce insulin. Problem is rejection by the body and taking pills to prevent rejection. It’s like being right on the doorstep of a cure for one of the most common diseases in this world and sitting there waiting waiting waiting.

Now, I strongly believe that curing something like diabetes would take billions of dollars away from your major drug companies and also prolong the lifes of many millions. I believe that the powers that be would not want this.

My question is, has anything been cured in the past 100 years which is a disease? Does anyone know of any promising diabetic research?

A: they probably have come up with cures many years ago, but do you really think that the pharmacy companies would allow the cures to be known public, where would they make their money at then?

Q: all of the following are disorders of the immune system except?
a. AIDS
b. multiple sclerosis
c. insulin dependent diabetes mellitus
d. HMC transplant rejection
e. rheumatoid arthritis

A: C.

Q: Since Recent Talk Of A Military Draft, Should The Military Lower Some of Its Standards, Such As:?
Allowing Diabetics to Join? I personally have asked to join every branch of the military and the same rejection that because I am Insulin Dependant Diabetic, I am unfit to serve my country.

A: i think they should change that. maybe restrict you from some things but theres no reason you shouldn’t get a cushy 96b like i had. (military intel, you usually sit at a computer or a map in air conditioning thousands ofmiles away from any fighting

Q: diabetic dog question……?
my much beloved 11 year old pound mixed breed mutt, charley, has diabetes. his diabetes has caused his tear ducts to quit working. in fact his ammune system is attacking his tear ducts. there is a expensive prescrption med for this called, “optimurine”. it contains the anti-rejection drug, cyclosporine, (excuse the poor spelling please). this stuff is about 50.00 bux per small tube, and combined with the expense of his insulin, needles, special food, and in general vet bills, well, i cant afford it all. does anyone have any info or alternetive treatments i could possibly try? thank you! jk.

A: Optimmune is wonderful, but 50 dollars is a bit expensive.

As much as I hate to tell you to do it, see if you can get it cheaper online. Petmeds has it for 34 dollars per tube.

http://www.medi-vet.com/detail.aspx~ID~2008 Has it for 24 dollars.

Confirm the dose and ask your vet for a script.

Even if they charge you a script fee, it’s going to be cheaper.

Most vets will give you a script…they may not like you to use the onlinerx companies…but hey, if you can save some money to give your pet good care….why not?

good luck!

Q: I wonder if this could be a cure for diabetes.?
OK SO HERE GOES. I have been diabetic type whatever I am for three years now. I have done massive amounts of research and came to the conclusion that diabetes is curable right now. I have spent the last three years figuring this out and I want some feed back as to what some might think:

This would be the generalized procedure I tried to make it as non invasive as possible.

Step 1: Haemopoietic Stem Cell Extraction.

Bone marrow contains Haemopoietic Stem Cells that the body regenerates. They are used to create red blood cells and released during emergencies to hasten the repair of tissue damage and expedites the healing process in extreme situations. Extract the bone marrow and use a process to separate the stem cells from the marrow.

2. Injection into area: ISLETS OF LANGERHANS : of the pancreas.

Take your newly acquired stem cells and have them injected into your this area of your pancreas to have your Islet cells repaired. The Islet cells create the ever important BETA CELLS, they manage sugars in the blood by releasing Insulin.

3. Sever all ability to feel pain in the pancreas region.

Disable the Neuro-Peptide that receives outward stimulus and converts it to a pain signal and sends the signal to the brain. Disabling the pain receptors in the pancreas will benefit the diabetic patient by eliminating inflammation. Reducing the inflammation to the area will allow the cells to thrive and regenerate quicker.

So here is an answer to some questions that may arise.

1. Stem Cells aren’t allowed to be used.

Not true. The issue of stem cells has always been a humanitarian one. It was argued that stem cells were harvested from live fetus’ and yes that is inhumane treatment of a human life. But this has to do with informed consent and the willingness of the patient to undergo the procedure. Since the stem cells belong to the patient there is no humanitarian issue as the patient has chosen to undergo the procedure and has been informed of the risks involved. The stem cells harvested would be only used for the intended purpose of organ restructuring and intense tissue damage repair.

2. The issue of rejection risk.

The risk is not even within the realm of likely. The fact that the Haemopoietic Stem Cells were specifically extracted from the marrow of the patient. Donor match is 100% likely…Rejection 0% likely.

3. Legal Issues

There are legal issues that prevent such procedures at times and in some states however if a patient has been properly informed of the risks and has consented and signed the waiver for the procedure there are no legal issues to be concerned with.

Okay. Now that I have presented my theory here, I would like to know if anyone has something to add.

Does it sound like a good procedure to build off of?

A: you know, it really wouldn’t hurt to pound the door of the american diabetes association until they patched you thru to a doc that could tell you why this wouldn’t work… my hunch is as with most diseases/disorders… genetic is the way to go… whats to stop this from reoccuring.. good luck with this, and truley if its buggin you, go for it… einstein didn’t let people who called him retarded stand in his way…

Q: Has anyone had experience or know of anyone who has been involved with online dating scammers from Nigeria?
A neighbour of mine has been involved. She has had a divorce, kidney transplant and suffers from diabetes. She rolled her Escalade (due to insulin shock) and lost her license. I have been volunteering one day a week for the last three months to run her to the doctor, shopping errands. She has been involved in an online dating site and hooked up over the internet with a guy that has scammed her for $5,000.00 and to this day she believes his stories that he is coming for Christmas.
He keeps coming up with excuses that he needs more money to leave Nigeria. A guy called claiming he was a doctor and this ‘guy’ needed money for a blood transfusion due to a motorcycle accident happened just a few hours ago.
I called the women’s abuse centre in our city and the police and both said that there was no crime committed.
Realistically, what are my options? I feel that it is her money and if she can send off $5,000.00 just like that, she can afford to spend that money on therapy when he dosen’t show up.
I feel the anti-rejection drugs, and her other health problems are interfering with her reasoning.
Any advice?
I have used my god given sense calling the abuse centre & the police. Right now I think I should sabotage her computer.

A: If your friend has family they need to step in and take power of attorney. I have a friend who was scammed for 1000.00, and while there is not a crime being committed because she sent the money freely and without contract she does need to be protected due to her health (not to mention her emotions) interfering with her reasoning.

A: It really depends on the person. I too take Metformin for PCOS and insulin resistance, and honestly for me, I went a few days without taking it, and the result was I felt dizzy, got a little headache or felt a little nauseated. Also, when it comes to consuming drinks with alcohol in it, and taking Metformin, what my doctor told me, when I asked this same question is to not drink alcohol often. If you are the type to have a drink once in a while, it would be fine, but if you are the type to drink a lot, then there would be a problem. The only suggestion I would give to you on that is, if I know I am going to have a drink that day, I will skip a dose, but I am in no way saying it is ok for you to do the same. The only reason I am able to do it is due to the fact that my last sugar test showed that they were in the right range they are suppose to be, and my doctor gave me an opinion of taking Metformin once or twice a day.

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